Inheritance Cube: MEDEA (Maternal Effect Dominant Embryonic Arrest)

This function creates an inheritance cube to model a MEDEA drive system. This system was first discovered in flour beetles. It biases inheritance by expressing a maternal toxin such that offspring die unless they express a zygotic antidote.
This drive has 3 alleles at 1 locus:

  • W: Wild-type allele

  • M: MEDEA allele

  • R: Resistance allele

cubeMEDEA(
  rM = 0,
  rW = 0,
  Teff = 1,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

rM

Breakdown of MEDEA allele, no homing/toxin/antidote, M -> R conversion
rW

De novo resistance generation, W -> R conversion
Teff

Efficacy of the toxin
eta

Genotype-specific mating fitness
phi

Genotype-specific sex ratio at emergence
omega

Genotype-specific multiplicative modifier of adult mortality
xiF

Genotype-specific female pupatory success
xiM

Genotype-specific male pupatory success
s

Genotype-specific fractional reduction(increase) in fertility

Value

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.