Inheritance Cube: CRISPR-SM (Clustered Regularly Interspaced Short Palindromic Repeats) with Small-Molecule Induction and 1 Resistance Allele and Maternal Deposition

This is a sex-specific version of CRISPR with small-molecule induced homing. It assumes that the construct is on an autosome and there can be different male/female homing rates. It also has maternal deposition, i.e., when the male provides a W allele to a female with a H allele, some portion are cut during oogenesis. Additionally, this cube is designed for small-molecule induction, i.e., with the SM branch of MGDrivE. It allows the homing (H) allele to be turned off into an O allele, which inherits stably, and so that all offspring of H individuals are O until turned on with the spray. If the maternal deposition parameters are zero (d* parameters), this is a normal CRISPR drive.

Usage

cubeHomingDriveSM(
  cM = 1,
  cF = 1,
  dF = 0,
  chM = 0,
  chF = 0,
  dhF = 0,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

cM: Male homing rate
cF: Female homing rate
dF: Female deposition homing rate
chM: Male correct homing rate
chF: Female correct homing rate
dhF: Female correct deposition rate
eta: Genotype-specific mating fitness
phi: Genotype-specific sex ratio at emergence
omega: Genotype-specific multiplicative modifier of adult mortality
xiF: Genotype-specific female pupatory success
xiM: Genotype-specific male pupatory success
s: Genotype-specific fractional reduction(increase) in fertility

Value

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.