Inheritance Cube: ECHACRX — cubeECHACRX • MGDrivE

This function creates an X-linked ECHACR construct, it has 5 alleles at the first locus and 4 alleles at the second.

W: Wild-type
H: Homing allele
E: Eraser allele
R: No-cost resistance allele
B: Detrimental resistance allele
cHW: Rate of homing from H, W -> H transition
cEH: Rate of homing from E, H -> E transition
cEW2: Rate of homing from E, W -> E transition

Usage

cubeECHACRX(
  cHW = 1,
  cEHW = 1,
  cEW1 = 1,
  cEW2 = 1,
  cEH = 1,
  chHW = 0,
  crHW = 0,
  chEHW = 0,
  crEHW = 0,
  ceEW1 = 0,
  crEW1 = 0,
  ceEW2 = 0,
  crEW2 = 0,
  ceEH = 0,
  crEH = 0,
  d1 = 0,
  d2 = 0,
  d3 = 0,
  dHW = 0,
  dEH = 0,
  dEW = 0,
  drHW = 0,
  drEH = 0,
  drEW = 0,
  crossF = 0,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

cHW: Cutting efficiency of drive allele at locus 1
cEHW: Cutting efficiency of drive allele, in the presence of ECHACR element, at locus 1
cEW1: Cutting efficiency of ECHACR element into W at locus 1
cEW2: Cutting efficiency of ECHACR element into W at locus 2
cEH: Cutting efficiency of ECHACR element into H
chHW: Homing efficiency of drive allele at locus 1
crHW: Resistance allele efficiency of drive allele at locus 1
chEHW: Homing efficiency of drive allele, in the presence of ECHACR element, at locus 1
crEHW: Resistance allele efficiency of drive allele, in the presence of ECHACR element, at locus 1
ceEW1: Homing efficiency of ECHACR element into W at locus 1
crEW1: Resistance allele efficiency of ECHACR element into W at locus 1
ceEW2: Homing efficiency of ECHACR element into W at locus 2
crEW2: Resistance allele efficiency of ECHACR element into W at locus 2
ceEH: Homing efficiency of ECHACR element into H
crEH: Resistance allele efficiency of ECHACR element into H
d1: Background mutation rate from W into R allele
d2: Background mutation rate from H into R allele
d3: Background mutation rate from E into R allele
dHW: Female H deposition rate against W
dEH: Female E deposition rate against H
dEW: Female E deposition rate against W
drHW: Female resistance generation rate, from H allele
drEH: Female resistance generation rate, from E allele
drEW: Female resistance generation rate, from E allele
crossF: Female crossover rate. 0 is fully linked, 0.5 is unlinked, 1 is negatively linked
eta: Genotype-specific mating fitness
phi: Genotype-specific sex ratio at emergence
omega: Genotype-specific multiplicative modifier of adult mortality
xiF: Genotype-specific female pupatory success
xiM: Genotype-specific male pupatory success
s: Genotype-specific fractional reduction(increase) in fertility

Value

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.

Details

This inheritance pattern corresponds to the Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives (doi:10.1016/j.molcel.2020.09.003 ) publication.