Inheritance Cube: ECHACRX

This function creates an X-linked ECHACR construct, it has 5 alleles at the first locus and 4 alleles at the second.

• W: Wild-type

• H: Homing allele

• E: Eraser allele

• R: No-cost resistance allele

• B: Detrimental resistance allele

• cHW: Rate of homing from H, W -> H transition

• cEH: Rate of homing from E, H -> E transition

• cEW2: Rate of homing from E, W -> E transition

cubeECHACRX(
  cHW = 1,
  cEHW = 1,
  cEW1 = 1,
  cEW2 = 1,
  cEH = 1,
  chHW = 0,
  crHW = 0,
  chEHW = 0,
  crEHW = 0,
  ceEW1 = 0,
  crEW1 = 0,
  ceEW2 = 0,
  crEW2 = 0,
  ceEH = 0,
  crEH = 0,
  d1 = 0,
  d2 = 0,
  d3 = 0,
  dHW = 0,
  dEH = 0,
  dEW = 0,
  drHW = 0,
  drEH = 0,
  drEW = 0,
  crossF = 0,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

cHW	Cutting efficiency of drive allele at locus 1
cEHW	Cutting efficiency of drive allele, in the presence of ECHACR element, at locus 1
cEW1	Cutting efficiency of ECHACR element into W at locus 1
cEW2	Cutting efficiency of ECHACR element into W at locus 2
cEH	Cutting efficiency of ECHACR element into H
chHW	Homing efficiency of drive allele at locus 1
crHW	Resistance allele efficiency of drive allele at locus 1
chEHW	Homing efficiency of drive allele, in the presence of ECHACR element, at locus 1
crEHW	Resistance allele efficiency of drive allele, in the presence of ECHACR element, at locus 1
ceEW1	Homing efficiency of ECHACR element into W at locus 1
crEW1	Resistance allele efficiency of ECHACR element into W at locus 1
ceEW2	Homing efficiency of ECHACR element into W at locus 2
crEW2	Resistance allele efficiency of ECHACR element into W at locus 2
ceEH	Homing efficiency of ECHACR element into H
crEH	Resistance allele efficiency of ECHACR element into H
d1	Background mutation rate from W into R allele
d2	Background mutation rate from H into R allele
d3	Background mutation rate from E into R allele
dHW	Female H deposition rate against W
dEH	Female E deposition rate against H
dEW	Female E deposition rate against W
drHW	Female resistance generation rate, from H allele
drEH	Female resistance generation rate, from E allele
drEW	Female resistance generation rate, from E allele
crossF	Female crossover rate. 0 is fully linked, 0.5 is unlinked, 1 is negatively linked
eta	Genotype-specific mating fitness
phi	Genotype-specific sex ratio at emergence
omega	Genotype-specific multiplicative modifier of adult mortality
xiF	Genotype-specific female pupatory success
xiM	Genotype-specific male pupatory success
s	Genotype-specific fractional reduction(increase) in fertility

Value

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.

Details

This inheritance pattern corresponds to the Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives publication.