This function creates an ECHACR construct, it has 5 alleles at the first locus and 4 alleles at the second.
W: Wild-type
H: Homing allele
E: Eraser allele
R: No-cost resistance allele
B: Detrimental resistance allele
cHW: Rate of homing from H, W -> H transition
cEH: Rate of homing from E, H -> E transition
cEW: Rate of homing from E, W -> E transition
Usage
cubeECHACR(
cHW = 1,
cEW = 1,
cEH = 1,
chHW = 0,
crHW = 0,
ceEW = 0,
crEW = 0,
ceEH = 0,
crEH = 0,
d1 = 0,
d2 = 0,
d3 = 0,
eta = NULL,
phi = NULL,
omega = NULL,
xiF = NULL,
xiM = NULL,
s = NULL
)Arguments
- cHW
Cutting efficiency of drive allele at locus 1
- cEW
Cutting efficiency of ECHACR element into W
- cEH
Cutting efficiency of ECHACR element into H
- chHW
Homing efficiency of drive allele at locus 1
- crHW
Resistance allele efficiency of drive allele at locus 1
- ceEW
Homing efficiency of ECHACR element into W
- crEW
Resistance allele efficiency of ECHACR element into W
- ceEH
Homing efficiency of ECHACR element into H
- crEH
Resistance allele efficiency of ECHACR element into H
- d1
Background mutation rate from W into R allele
- d2
Background mutation rate from H into R allele
- d3
Background mutation rate from E into R allele
- eta
Genotype-specific mating fitness
- phi
Genotype-specific sex ratio at emergence
- omega
Genotype-specific multiplicative modifier of adult mortality
- xiF
Genotype-specific female pupatory success
- xiM
Genotype-specific male pupatory success
- s
Genotype-specific fractional reduction(increase) in fertility
Value
Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.
Details
This inheritance pattern corresponds to the Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives (doi:10.1016/j.molcel.2020.09.003 ) publication.