Inheritance Cube: ECHACR

This function creates an ECHACR construct, it has 5 alleles at the first locus and 4 alleles at the second.

  • W: Wild-type

  • H: Homing allele

  • E: Eraser allele

  • R: No-cost resistance allele

  • B: Detrimental resistance allele

  • cHW: Rate of homing from H, W -> H transition

  • cEH: Rate of homing from E, H -> E transition

  • cEW: Rate of homing from E, W -> E transition

cubeECHACR(
  cHW = 1,
  cEW = 1,
  cEH = 1,
  chHW = 0,
  crHW = 0,
  ceEW = 0,
  crEW = 0,
  ceEH = 0,
  crEH = 0,
  d1 = 0,
  d2 = 0,
  d3 = 0,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

cHW

Cutting efficiency of drive allele at locus 1
cEW

Cutting efficiency of ECHACR element into W
cEH

Cutting efficiency of ECHACR element into H
chHW

Homing efficiency of drive allele at locus 1
crHW

Resistance allele efficiency of drive allele at locus 1
ceEW

Homing efficiency of ECHACR element into W
crEW

Resistance allele efficiency of ECHACR element into W
ceEH

Homing efficiency of ECHACR element into H
crEH

Resistance allele efficiency of ECHACR element into H
d1

Background mutation rate from W into R allele
d2

Background mutation rate from H into R allele
d3

Background mutation rate from E into R allele
eta

Genotype-specific mating fitness
phi

Genotype-specific sex ratio at emergence
omega

Genotype-specific multiplicative modifier of adult mortality
xiF

Genotype-specific female pupatory success
xiM

Genotype-specific male pupatory success
s

Genotype-specific fractional reduction(increase) in fertility

Value

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.

Details

This inheritance pattern corresponds to the Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives publication.